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师资队伍

林宁

林宁，男，博士，研究员/教授，博士/硕士研究生导师，药物化学教研室主任，药物化学学科负责人，广西中医大学桂派杏林拔尖人才，广西壮瑶药工程技术研究中心核心成员，中国民族医药学会方药量效研究分会常务理事，中国民族医药学会壮医药分会常务理事，中国民族医药学会医养结合分会理事，广西、江苏、江西科技项目评估咨询专家。主持国家自然科学基金3项，广西自然科学基金重点项目1项、面上项目2项，beat365平台唯一官网中药学优势学科建设专项课题1项。在Rare Met.、Eur. J. Med. Chem.、Org. Lett.、Org. Chem. Front.、J. Org. Chem.和Cryst. Growth Des.等学术期刊发表SCI论文40多篇，授权国家发明专利9件。获中国民族医药学会科学技术奖二等奖1项，beat365平台唯一官网教学成果一等奖1项。主讲本科及硕士研究生的《药物化学专论》、《药物化学》、《药物合成反应》、《制药工艺学》及《药学专业英语》等课程。

招生专业：药物化学、中药学

研究方向：药物分子设计合成及活性、中药活性成分研究与应用、手性药物技术、药物绿色高效合成方法

联系方式：linning@gxtcmu.edu.cn



教研室人员信息表

近年发表的学术论文

(1) Jie-Jie Lai, Yue-Hua Zhang, Yu-Cui Lu, Hai-Li Wu, Shun Zhang, Xia-Yun Liao, Qing Chen*, Ning Lin*, Cai-Wu Jiang*. Structure and enhanced biopharmaceutical properties of dihydromyricetincocrystal: Supramolecular architecture, solubility and bioactivity, J. Mol. Struct., 2026, 1355, 145057.

(2) Ling Chen, Xiao-Qin Ma, Hai-Li Wu, Shun Zhang, Jie-Feng Chen, Ning Lin*, and Qing Chen*. Resveratrol−Temozolomide Cocrystal Induced Antiglioblastoma Effects via Enhanced Dissolution Behavior and Mitochondrial Apoptosis, Cryst. Growth Des., 2025, 25, 9899−9907.

(3) Xiao-Xuan Zeng, Bo-Cheng Chen, Xiang-Xin Cao, Dong-Wei Ma, Jing-Sheng Lu Yu-Ting Huang, Zi-Qian Zhang, Gang Wang, Ning Lin*, Qing Chen*. Zinc-based metal–organic frameworks as efficient carriers in combination therapy for hepatocellular carcinoma treatment, Inorg. Chem. Commun., 2025, 174, 113921.

(4) Xiao-Xuan Zeng, Jing-Sheng Lu, Dong-Wei Ma, Yu-Ting Huang, Ling Chen, Gang Wang, Qing Chen*, Ning Lin*. Application of nanoscale metal–organic frameworks in tumor immunotherapy, Rare Met., 2024, 43, 4867-4883.

(5) Jin-Zhi He, Bao-Lei Zhu, Zhen-Hui Huang, Jin-Ping Liang, Zhen-Wei Zhang*, Qing Chen*, and Ning Lin*. Asymmetric Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines and Unsymmetrical Dicarbonyl-Activated Alkenes: Con-struction of 5'-Trifluoromethylated 3,2'-Pyrrolidinyl Spirooxin-doles with Three Carbonyl Groups, J. Org. Chem. 2024, 89, 12924−12934.

(6) Dong-Wei Ma, Jing-Sheng Lu, Xiang-Xin Cao, Yan-Wei Cheng, Gang Wang, Zi-Qian Zhang, Bo-Cheng Chen, Ning Lin*, Qing Chen*. Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy, Rare Met., 2024, 43, 5152-5163.

(7) Yang-Ling Li, Yan-Wei Cheng, Ying-Qi Zhang, Hui-Ling Nan, Ning Lin*, Qing Chen*.  Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis, Phytochemical Analysis, 2024, 35, 1–13.

(8) Dong-Wei Ma, Gang Wang, Jing-Sheng Lu, Xiao-Xuan Zeng, Yan-Wei Cheng, Zhen-Wei Zhang, Ning Lin*, and Qing Chen*. Multifunctional nano MOF drug delivery platform in combination therapy, Eur. J. Med. Chem., 2023, 261, 115884.

(9) Feng-Ji Zhou, Bao-Lei Zhu, Zhen-Hui Huang, Ning Lin*, Zhen-Wei Zhang*.  DBU-catalyzed diastereoselective 1,3-dipolar [3+2] cycloaddition of trifluoroethyl amine-derived isatin ketimines with chalcones: synthesis of 5′-CF3 substituted 3,2′-pyrrolidinyl spirooxindoles, RSC Adv., 2024, 14,548–551.

(10) Wen-Run Zhu, Kai Liu, Jiang Weng*, Wei-Hua Huang, Wei-Jie Huang, Qing Chen, Ning Lin*, and Gui Lu*. Catalytic Asymmetric Synthesis of Vicinal Diamines Bearing Quaternary-Quaternary Stereocenters via Umpolung Cross-Mannich Reaction of Cyclic Ketimines, Org. Lett., 2020, 22, 5014-5019.

(11) Wen-Run Zhu, Qiong Su, Ning Lin*, Qing Chen*, Zhen-Wei Zhang, Jiang Weng, Gui Lu*. Organocatalytic Synthesis of Chiral CF3-Containing Oxazolidines and 1,2-Amino Alcohols: Asymmetric oxa-1,3-Dipolar Cycloaddition of Trifluoroethylamine-Derived Azomethine Ylide, Org. Chem. Front., 2020, 7, 3452–3458.

(12) Wei-Peng Zhong, Qi-Wei Chen, Xiang-Xin Cao, Shui-Li Liu, Qing Chen,* Ning Lin*. A zinc(II) sulfate-based porous framework with new topology and its usage as catalyst in Friedel–Crafts alkylation reaction, Inorg. Chem. Commun., 2020, 119, 108037.

(13) Zhen-Wei Zhang*, Shao-Wu Liu, Hong-Ping Huang, Yu-Hang Xie, Ruo-Chen Huang, Yan-Qiu Deng*, Ning Lin*. Dehydroabietane-type bifunctional  organocatalysts in asymmetric synthesis: recent  progress, RSC Adv., 2023, 13, 31047–31058.

(14) Ning Lin*, Qiu-Xiang Wei, Li-Hua Jiang, Yan-Qiu Deng, Zhen-Wei Zhang*, Qing Chen. Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide, Catalysts, 2020, 10, 14.

(15) Xiao-Qin Ma, Chong Zhuang, Bi-Chuan Wang, Yuan-Feng Huang, Qing Chen*, Ning Lin*. Cocrystal of Apigenin with Higher Solubility, Enhanced Oral Bioavailability, and Anti-inflammatory Effect, Cryst. Growth Des., 2019, 19, 5531−5537.

(16) Wen-Run Zhu, Zhen-Wei Zhang, Wei-Hua Huang, Ning Lin*, Qing Chen*, Kai-Bin Chen, Bi-Chuan Wang, Jiang Weng, Gui Lu*. Asymmetric synthesis of vicinally bis(trifluoromethyl)-substituted 3,3’-pyrrolidinyl spirooxindoles via organocatalytic 1,3-dipolar cycloaddition reactions, Synthesis, 2019, 51, 1969−1979.

(17) Wen-Run Zhu, Qing Chen, Ning Lin*, Kai-Bin Chen, Zhen-Wei Zhang, Gang Fang, Jiang Weng, Gui Lu*. Organocatalytic Michael/cyclization cascade reactions of 3-isothiocyanato oxindoles with 3-trifluoroethylidene oxindoles: approach for the synthesis of 3′-trifluoromethyl substituted 3,2′-pyrrolidinyl-bispirooxindoles, Org. Chem. Front., 2018, 5, 1375−1380.

(18) Ning Lin*, Xian-wen Long, Qing Chen, Wen-run Zhu, Bi-chuan Wang, Kai-bin Chen, Cai-wu Jiang, Jiang Weng*, Gui Lu*. Highly efficient construction of chiral dispirocyclic oxindole/thiobutyrolactam/chromanone complexes through Michael/cyclization cascade reactions with a rosin-based squaramide catalyst, Tetrahedron, 2018, 74, 3734–3741.

(19) Wei-Jie Huang, Qing Chen, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong, Jiang Weng*, Gui Lu*. Asymmetric synthesis of trifluoromethylsubstituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions, Org. Chem. Front., 2017, 4, 472–482.

(20) Wei-Jie Huang, Qing Chen, Wen-Run Zhu, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Jiang Weng*, Gui Lu. Highly efficient construction of cf3-containing 3,3′-pyrrolidinyl-dispirooxindoles via base-catalyzeddiastereoselective [3+2] annulation, Heterocycles, 2017, 94, 879−893.